Tuesday, October 9, 2018, 2:00 pm EDT
Nicotine is the primary addictive component of tobacco. We now know a great deal about the targets for nicotine in the brain and the circuits involved in its behavioral effects. There is also a longstanding association between tobacco smoking, anxiety and depressive disorders. In this presentation, I will discuss studies in mice and humans that have identified the targets and brain areas that are important for the addictive effects of nicotine and how this relates to brain circuits that are impaired in individuals with anxiety and depression.
Marina R. Picciotto, Ph.D.
Yale University School of Medicine
Charles BG Murphy Professor in Psychiatry and Deputy Chair for Basic Science
Professor of Neurobiology and Pharmacology and in the Child Study Center
Scientific Council Member (Joined 2015)
2016 Distinguished Investigator Grant
2004 Independent Investigator Grant
1996 Young Investigator Grant
Marina Picciotto is Charles B.G. Murphy Professor and Deputy Chair for Basic Science in Psychiatry at Yale University. She is also Professor of Neurobiology, Pharmacology and in the Child Study Center. Her research focuses on defining molecular mechanisms underlying behaviors related to psychiatric illness, with a focus on the function of nicotinic acetylcholine receptors in the brain. Her laboratory uses molecular genetic strategies to identify the role of individual molecules in behaviors related to depression, addiction, cognitive function and food intake. Dr. Picciotto received her B.S. from Stanford and her Ph.D. from The Rockefeller University where she worked with Dr. Paul Greengard. She conducted postdoctoral work with Professor Jean-Pierre Changeux at the Pasteur Institute before joining the faculty at Yale University. Dr. Picciotto is Treasurer of the Society for Neuroscience, interim Editor in Chief of the Journal of Neuroscience, and serves as handling editor or on the editorial board of several journals. She is a fellow of AAAS and a member of the National Academy of Medicine.