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Patient Recruitment for Studies Conducted by the NIMH, NIH:  We conduct a large number of research studies with patients who have mental health disorders. Our studies are performed at the NIH Clinical Center (CC), a hospital dedicated to the highest quality research. The NIH CC (picture shown on the right) is located in Bethesda, Maryland, near Washington, D.C.  We want to provide you with information about our research and about your disease to help you decide whether to volunteer for participation in one of our studies. If you qualify for a study, then study-related evaluation, treatment and, in some cases, transportation to NIH are provided without cost to you or your health plan.

Read A Participant’s Guide to Mental Health Clinical Research Online or download the guide nimh-participants-guide (PDF)

Clinical Trials.govRegistry of federally and privately supported clinical trials conducted in the United States and around the world. Gives you information about a trial’s purpose, who may participate, locations, and phone numbers for more details: http://clinicaltrials.gov/ Behaviors and Mental Disorders[CONDITION-BROWSE-BRANCH] | Open Studies | “Depression” | United States, Massachusetts | NIH, U.S. Fed

Clinical Connection, a source for timely clinical trials information, listings, and notifications.

The Schizophrenia Research Forum website—a virtual community for science about schizophrenia and related disorders. Our Mission is to help researchers in their quest for causes, improved treatments, and better understanding of schizophrenia. http://www.schizophreniaforum.org/

Search Clinical Trials is an easy way to find a clinical trial that may be right for you.

Go to PubMED – An electronic search engine of scientific articles published in thousands of journals across the world. It is hosted by the National Library of Medicine at the National Institutes of Health


Local Research Studies in Progress:

Depression Studies

Internet Based Cognitive Behavioral Therapy Effects on Depressive Cognitions and Brain Function

Do you have depression? Are you in a relationship with someone who has depression?

Have You Been Feeling Depressed, Down or blue for the past 2 weeks?

Have You Been Feeling Depressed, Down or Blue in the Past 2 weeks? Do you also smoke marijuana?

Study Volunteers for Females aged 15-19 yrs old currently suffering with Depression or Parents with daughters aged 15-19 yrs old currently suffering with Depression

ActivMed Practices and Research are looking for volunteers to participate in a nationwide study on major depressive disorder

Seeking Individuals With Depression Between 18-45 for a Research Study of the Effects of Internet-Based Cognitive Behavioral Therapy (PDF)

Study of Depression in Romantic Relationships – U Illinois Urbana-Champaign(Word)

Project ADAPT and Project STAR are looking for adolescents between the ages of 13 and 18 yrs (Word)

University of New England RateADrug Depression Feedback survey (Word)

Drug Free Treatment for Depression in Teens and Young Adults in Rhode Island and Cambridge (PDF)

Mood Memos is a University of Melbourne study exploring a method of preventing depression through the internet. The study is targeted to people experiencing some depression symptoms who are not yet too severe, with the aim of averting depression or relapse (Word)

Mood and Menopause Study at UMass (PDF)


Bipolar Disorder Studies

B-SNIP2 Study: An observational research study for people 18-60 years old with a diagnosis of bipolar with psychotic features, schizophrenia, schizoaffective disorder

6-week research study that looks at sleep disturbance in individuals with bipolar disorder (Word)

ActiveMed Practices & Research is currently enrolling the following studies.docx (Word)

Bipolar Disorder study for participants ages 12 to 17 years and generally healthy (Word)

Bipolar and Menopause Research Study – UMASS Medical School (Word)

Bipolar Depression Study at St. Elizabeth and McLean Hospital (Word)

The aim of the research is to find out whether factors such as impulsivity and time perspective can predict the onset of bipolar depression and mania. Survery with all materials-R überarbeitet

The Evaluation of Lamictal as an Add-On Treatment for Bipolar I Disorder in Children and Adolescents, 10 to 17 Years of Age (PDF)

Have you ever been diagnosed with Bipolar Disorder or mania? Do you have a 3 to 5 year-old child? Mass General Study (PDF)



Schizophrenia and Psychosis Studies

The What Now Project is developing an innovative website to support family members of individuals with schizophrenia and we’re conducting this study to find out how much it will help families likes yours. To get started in the study, please complete this online questionnaire. It will take you approximately 20-30 minutes https://goo.gl/forms/V3Zp26ULmtVLJuIF2

Human Connectome Project: An observational research study for people recently diagnosed with a psychotic disorder https://www.bidmc.org/research/research-by-department/psychiatry/commonwealth-research-center/current-research-studies/connectome-study

CLUES Study: A treatment study for people at clinical and genetic high risk for psychosis http://cedarclinic.org/index.php/research-programs/clues


NAPLS III Study: A longitudinal research study for people at clinical high risk for psychosis http://cedarclinic.org/index.php?option=com_content&view=article&id=66&Itemid=68


Do you have a family member with schizophrenia?

BU Psychiatric Rehabilitation Research Study: Exercise and Cognitive Training for Individuals with Schizophrenia

Healthy Adolescents with Psychotic First Degree Relative Effects of Folate Fortification on Brain Development II: Family Studies of Psychosis

Are you diagnosed with a serious mental illness like Schizophrenia, Schizoaffective Disorder, Major Depressive Disorder, Bipolar Disorder or Psychosis NOS?

Schizophrenia Neurobiology Study Flier

Pilot research project beginning at the Recovery Center, Center for Psychiatric Rehabilitation (CPR), aimed at evaluating the potentially synergistic effects of aerobic exercise and cognitive remediation in people with schizophrenia.

Researchers at the Psychotic Disorders Program in the Dept. of Psychiatry at UMass Med School are looking for volunteers for four (4) different studies

UMass Medical School Child and Adolescent NeuroDevelopment Initiative  (CANDI)  are looking for 8 more adolescents with a schizophrenia diagnosis to participate in the Investigational Drug Study for Adolescents with Schizophrenia. For more information about the study, please call us at 774-455-4100 or email us at ChildResearch@umassmed.edu.

Researchers at Tufts Medical Center/Tufts University are recruiting 1,000 caregivers of individuals diagnosed with schizophrenia and/or schizoaffective disorder. 

Has your child been hearing things that are not there? (Study conducted by Social Neuroscience and Psychopathology lab at Harvard University)

Does your child or teen have a parent or sibling with schizophrenia or schizoaffective disorder? (Study conducted by Social Neuroscience and Psychopathology lab at Harvard University)

Boston VA Healthcare Systems and Amgen Searching for Candidate Genetic Defects for Schizophrenia Using the Latest Genetic Technology (PDF)

Three-Studies re Schizophrenia – The Psychotic Disorders Research Program at UMass Medical School in Worcester, MA (PDF)

The NIHM Genetic Study of Schizophrenia. Individuals 18 years old or older diagnosed with schizophrenia or schizo-affective disorder (depressed type) may be able to participate in a genetic study that looks for genes in families. In order for family members to participate, the person with schizophrenia must be willing and able to participate. Eligible family members participate in an interview and contribute a sample of blood for genetic analysis. Individuals with schizophrenia, and if possible, their siblings, may qualify to participate in this study. There is no change in medication involved. The study involves simple cognitive tests and some MRI scans (no radiation). All testing is completed free of charge and there is compensation for each family member’s participation in the study. Travel and lodging assistance is also available. Scientists believe that the identification of susceptibility genes is key to understanding the molecular pathways of this disease so that better treatments and preventive methods can be developed in the future. To find out more, please call 301-435-8970 (1-888-674-6464) or email schizophrenia@mail.nih.gov. For more information on research conducted by the National Institute of Mental Health in Bethesda, MD click here:  Read

Schizophrenia Trial for participants ages 12 – 17 years and generally healthy (Word)

NIMH RAISE (Recovery After an Initial Schizophrenia Episode) research project is now actively recruiting participants (Word)

Do you have a close relative (parent, sibling, child) who has schizophrenia or schizoaffective disorder (Word)

Schizophrenia Study at St. Elizabeth’s Hospital (Word)

SearchLyte Study on Schizophrenia (Word)

Research Study – Harvard University Social Neuroscience and Psychopathology Lab Have you been diagnosed with Schizophrenia or Schizoaffective disorder? (Word)

Help Participate in a Research Study Comparing the Brains of People With and Without a Family History of Schizophrenia (Word)

Biological Predictors of Psychosis Susceptibility among Adolescent Cannabis Users” Harvard Medical School(Word)


OCD Studies

These studies aim to test the effectiveness of two new treatments for OCD, and to help us understand what changes in the brain during these treatments.

A research study is now enrolling for those who still need help controlling their OCD symptoms. This particular study is looking for people who are still experiencing OCD symptoms despite taking Luvox, Prozac, Paxil, or Zoloft. OCD Clinical Trial News Release (PDF)

Have Obsessive Compulsive Disorder? Interested in learning more? Willing to consider some brain scans (MRI? PET?) or a 14-week medication study? For more info click on this OCD Research Study or Clinical Trial (PDF)  http://psychiatry.yale.edu/ocd/participate/participate.aspx



SPARCS Sleep Study: A research study of sleep in people with early psychosis and genetic risk for psychosis, (first-degree relatives.)

Survey – Knowledge of Metabolic Risk in People with Mental Health Problems

Is your child/adolescent suffering from tics and ADHD? If you have a child aged 10-17 who is bothered by tics and ADHD symptoms, we may be able to help.

McLean Hospital is carrying out a genetic study of psychotic disorders that focuses on de novo (non-inherited) mutations

Temple University Collaborative research study of distance supported evidence: volunteers in school with mental health issues

An Exploratory Study to Evaluate the Experiences within Acute Psychiatric Wards from the Staff and Patient Perspective

Are you interested in participating in a research study about how diverse adults with psychiatric conditions view work?

The purpose of this research study is to learn which of two different forms of therapy is more likely to help individuals who have body image concerns.


Research Study for Parents Whose Adult Child has a Serious Mental Illness

Moms with Disabilities Survey Flyer (PDF)

Study Invitation for Parents Caregiving for an Adult Child with Serious Mental Illness

ActivMed Practices and Research are looking for volunteers to participate in a new clinical trial on anxiety.

The MGH Center for Women’s Mental Health has a special registry studying the use of atypical antipsychotic medications during pregnancy. All pregnant women ages 18-45 are eligible to enroll in the registry, whether or not they are taking these medications.

The BU School of Social Work, Asian Womens Health Initiative Project, is Currently Recruiting Participants for the Aware Intervention Research Study

Are you the parent of a child with a mood disorder with or without a history of trauma

Study on The Experience of Stigma by Family Members of Individuals with Severe Mental Illness

If you have a family member with live experience with mental illness who may have had an interaction with law enforcement? Please download the Share Your Experience Flyer for more information.

Particpate in Sleep Rearch at Massachusetts General Hospital

Are you 18 years or older and experience thoughts or feelings related to suicide?

Understanding the experiences of individuals with serious mental illness I am a graduate student in Clinical Psychology at Bowling Green State University in Ohio. My dissertation project involves better understanding the experiences of individuals with serious mental illness. I am interested in learning more about how people recover from mental health problems and about the losses they experience. Participation in this study involves completing an online questionnaire at your convenience. I estimate that it will take you no longer than 30-45 minutes to complete this survey. If you have been diagnosed with a serious mental illness such as schizophrenia, schizoaffective disorder, bipolar disorder, or major depression, please consider participating in this important study. Contact Jaclyn Leith at jleith@bgsu.edu or at 419-372-4596 in order to express your interest in participating and gain access to the online survey link. For your participation in this study, you will be given a $5 gift card from your choice of one of two major retailers (Target or Amazon.com).

Families Needed for Research Study and the Parent has a Diagnosis of Schizophrenia or Schizoaffective Disorder (PDF)

UMass Medical School’s Center for Health Policy and Research is conducting a study to understand the types of health care services people with disabilities need in order to work or return to work. (PDF)

Internet Education & Social Support Research Study For Mother’s Diagnosed With A Mental Illness (PDF)

Project Implicit Mental Health: learn about the measurement of thoughts about self-harm, anxiety, depression, and other factors that may exist outside your conscious awareness or control.

An internet parenting education and research study (PDF) online parenting education and support group, part of a national research study testing the effectiveness of such a program for mothers with a psychiatric disability

Would you like to contribute to exciting research about hearing voices, as well as have the chance to win Amazon vouchers? A research group based at the University of Surrey in the UK want to find out more about the experiences of people who hear voices. The research group want to know what is most important to help people recover, and build a satisfying life. They hope to improve the treatments offered to people who hear voices, by showing what is most important to voice hearers.  You can visit their website today at www.fahs.surrey.ac.uk/survey/voices to find out more. They will ask you to answer some questions, which should take roughly 25 minutes. To thank you for your time, they will enter those who take part into a raffle to win Amazon vouchers worth up to $75! Please contact the researchers Alison Holt (a.holt@surrey.ac.uk) or Esther Clarke (e.clarke@surrey.ac.uk) for any further information.

The Child and Adolescent NeuroDevelopment Initiative (CANDI) conducts on-going research in early-onset bipolar disorder, psychotic disorders, and autism spectrum disorders (Word)

Study of families of mental health consumers and their experiences with law enforecement BU Study (Word)

Research Study – Harvard University Social Neuroscience and Psychopathology Lab Ages 15 -30 (Word)

Research Study – children ages 8-11 – how the brain processes social situations and how this relates to children’s experiences of the world around them and their social relationships (Word)

Participants needed for a research study at the Boston University Center for Psychiatric Rehabilitation is conducting a research study on how adults with psychiatric conditions view work BU Psych Rehab Work Research Study (PDF)

Study of Housing in the Lives of Young Adults with Mental Health Conditions (PDF)

American Foundation for Suicide Prevention (AFSP): Survivor Research – Online Study of Grief-Related Experiences. Complicated Grief Study Seeks Participants in Boston

Teens Needed for Research Study on Physical Activity Choices (Word) The Eunice Kennedy Shriver Center at the University of Massachusetts Medical School in Waltham, MA